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Let’s delve into the fascinating world of NHP (nonhuman primate) implant chambers. These specialized devices play a crucial role in neuroscience research involving our primate cousins. 🐒🧠

1. Acrylic-Free Implants:
   • Traditionally, head fixation devices and recording cylinders for NHP research have been made using dental acrylic. However, acrylic has its limitations.
   • Researchers are increasingly turning to more biocompatible materials such as titanium and PEEK (polyether ether ketone).
   • A recent study describes a cost-effective approach to maximize the integration of headposts and recording cylinders with the animal’s tissues while reducing surgery time.
   • Here’s how it works:
     • Three-Dimensional Printed Skull Replica: Based on computerized tomography scans, a 3D printed replica of the monkey’s skull is created.
     • Titanium Headposts: The titanium feet of the headposts are shaped, and the skull thickness is measured preoperatively, reducing surgery time by up to 70%.
     • Recording Cylinder: The recording cylinder is manufactured to conform tightly to the skull, fastened with screws, and remains watertight for extended periods (up to 8.5 months).
     • Skin Regression: While there’s variability in skin regression around the headpost, no cases of bone exposure were observed. Skin adhered to the skull adjacent to the titanium regions.
     • Longevity: These acrylic-free implants remained fully functional and complication-free for the experimental life of each animal, some of which participated in experiments for over 4 years after implantation¹.
2. Care of Cranial Implants and Chambers:
   • Routine care and cleaning of head fixation implants and recording chambers are essential.
   • Regular maintenance ensures the longevity and functionality of these critical tools in NHP research.
   • Researchers and caregivers are responsible for following standard operating procedures (SOPs) to maintain the well-being of the animals and the integrity of the implants².
3. Advancements in Imaging Techniques:
   • Some implant chambers are designed to enhance recording window longevity.
   • By regulating pressure and allowing a larger field of view, these chambers can be critical for both NHP and human brain imaging.
   • These innovations facilitate various imaging techniques used in neurophysiology research³.

In summary, NHP implant chambers are at the forefront of cutting-edge neuroscience research, enabling us to explore the intricacies of primate brains and unravel the mysteries of cognition and behavior. 🧠🔬🐵

Learn more

1journals.physiology.org 2mcgill.ca 3jneurosci.org